Adrion left his native town of Strasbourg in 1907 and moved to Paris to work as a draftsman to the fashion industry. He travelled to London, Munich and Frankfurt. When he visited Germany the outbreak of the First World War meant he was demobilised in Berlin. Here Adrion studied at the studio of Hermann Struck (1876-1944), a well-known artist in etchings and engravings who was also the master of artists such as Marc Chagall (1887-1985) and Lesser Ury (1861-1931). Adrion remained in Berlin until after the end of the First World War, and returned to Strasbourg in 1919.
His signed lithographs were a success and monetarily fuelled his travels back to Paris. Georges Chéron an art dealer who also represented artists like Amadeo Modigliani and Foujita, staged a One-man Show of Adrion's work in February 1921 and represented him henceforth. In the neighbourhood of Montparnasse, Adrion associated with young Eastern European painters such as Chaime Soutine (1893-1943), Pinchus Krémegne (1890-1981) and Michel Kikoine (1892-1968) who were to comprise the École de Paris Group.
The artist was greatly appreciated for his crowded street scenes around Paris. For example, the critic Galtier-Boissiére, (1891-1966) wrote, "Il a le sens du mouvement des foules, du mouvement de la vie." (He has a feeling for the movement of crowds, the movement of life.) There is a distinct shift in Adrion's later style, when bored with his life in Paris he left his agent Chéron for Normandy and focused on painting landscapes. These were again successful and gained great popularity. His paintings are not only in French collections but throughout Europe and the United States